Memorial Presbyterian Church faithfully supports individual missionaries and ministry organizations in the United States and world-wide through prayer, financial support, and hands-on support. Church members of all ages are actively involved in mission projects, local and long distance, short and long-term, organized both through the church and various ministry organizations.

The Congregation supports one another through genuine caring and hospitality. An organized Prayer Chain supports the ministry of prayer within the congregation. The Board of Deacons reaches out to shut-ins, sends greetings to students away at college, make hospital visits, and greets new visitors to the church. In the local community, the church supports ongoing projects such as the food pantry, the school and Mid Sioux Opportunity. Members of the congregation were actively involved with local flood relief efforts in 2013 through both financial contributions and hands on clean-up. In addition, church members are involved with Meals on Wheels, Prayer Shawl, and donations of school supplies, hats and mittens.

The Mission Committee selects Mission Partners and special offerings are received to support them. Recent Mission Partners have included: Cherokee Food Pantry, Cherokee County Emergency Fund, Laborers with Christ, Gideons, P.E.T., Heifer International, Habitat for Humanity, Salvation Army, Cherish Center, Lakeshore Center at Okoboji, One Great Hour of Sharing and Christmas Joy Offering.

Memorial Presbyterian Church was blessed to send Mission teams to Haiti in 2013 and 2014. In 2014, the Mission Team, consisting of 6 members, traveled to Les Cayes, and worked at the Consolation Center, painting, welding, and even helping with some farming. They spent time worshiping and playing with the children of the three orphanages sponsored by Global Compassion International and Laborers with Christ: The Consolation Center, the Center for Help, and the James 1:27 Project.